Bilkent University
Department of Computer Engineering


Discovering Non-coding RNA Regulatory Interactions


Gülden Olgun
PhD Student
Computer Engineering Department
Bilkent University

High-throughput sequencing technologies reveal that beyond protein-coding genes, there are a large number of RNAs that do not encode for proteins. These non-coding RNAs(ncRNAs) are emerging as key regulators of the cellular processes and their alteration is implicated in many diseases including cancer. One type of ncRNA is the microRNA; this is a small RNA that regulate gene expression levels post-transcriptionally through binding to their target messenger RNAs(mRNA). Another type is the long non-coding RNA(lncRNAs) and it has been recently discovered to act as a sponge for microRNAs. By reducing the amount of microRNAs available to target mRNAs, it indirectly affects the mRNA expression levels. Using the expression profiles of breast cancer patients, we aim to identify these microRNA-mediated sponge interactions specific to breast cancer subtypes. We also analyzed the relationship between sponge interactions specific to breast cancer subtypes and patient survival.


DATE: 21 November, 2016, Monday @ 16:00